The Unipept web application supports biodiversity and functional analysis of large and complex metaproteome samples. Its underlying index structure is designed to quickly retrieve all occurrences of a tryptic peptide in UniProt entries. Taxon-specificity of the tryptic peptide is successively derived from these occurrences using a novel lowest common ancestor approach that is robust against taxonomic misarrangements, misidentifications and inaccuracies. This application consists of four separate functionalities: the Tryptic Peptide Analysis, the Metaproteomics Analysis, the Unique Peptide Finder and the Peptidome Clustering.
The initial Unipept publication can be found at Unipept: tryptic peptide-based biodiversity analysis of metaproteome samples, a follow up publication can be found at The Unipept Metaproteomics Analysis Pipeline. The API was published as Unipept Web Services for Metaproteomics Analysis.
How to cite Unipept
If you use Unipept for your research, please cite:
- CLI: Mesuere et al. (2017) Journal of Proteomics doi:10.1016/j.jprot.2017.05.022
- Peptidome Analysis: Mesuere et al. (2016) Proteomics doi:10.1002/pmic.201600023
- API: Mesuere et al. (2016) Bioinformatics doi:10.1093/bioinformatics/btw039
- General: Gurdeep Singh et al. (2019) Journal of Proteome Research doi:10.1021/acs.jproteome.8b00716
- General: Mesuere et al. (2015) Proteomics doi:10.1002/pmic.201400361
- General: Mesuere et al. (2012) J. Proteome Res. doi:10.1021/pr300576s
- Bart Mesuere Postdoc and lead developer
- Pieter Verschaffelt Master's student 2018-2019
- Felix Van der Jeugt PhD student
- Peter Dawyndt P.I.
- Lennart Martens P.I.
- Robbert Gurdeep Singh Developer 2017-2018
- Toon Willems Master's student 2013-2014
- Tom Naessens Master's student 2014-2015
- Peter Vandamme Advisor
- Bart Devreese Advisor
For indivitual contributions, the github contributors page is the most informative.
We make no warranties regarding the correctness of the data, and disclaim liability for damages resulting from its use.